We discussed this topic in our last video conference call and I took a second look at the subject.
Why do medications like ORAP (pimozide), Zyprexa, Abilify, Risperdal, Wellbrutrin, Olanzapine, Zolof, and Serequel that are listed in my book, How to Get Your Life Back from Morgellons... have in common? Is it that they are only used for those suffering from psychosis meaning we're all psychotic? or is it because they affect levels of dopamine? This has been a long standing question that may be finally answered.
The answer is in this article, sent to me by Julia, which states, "Pimozide inhibits parasite invasion and replication." This article is about Toxoplasmais which is the Toxoplasma gondii parasite-- According to the CDC,"Toxoplasmosis is considered to be a leading cause of death attributed to foodborne illness in the United States." It is a protozoa parasite that is often a co factor in those with Lyme disease and "More than 40 million men, women, and children in the U.S. carry the Toxoplasma parasite."
But, while many of us may have this protozoan parasite, all of us are dealing with one or more of the following: Morgellons, mites, and Collembola. While the study does not mention dopamine, I searched for "the effect of (name of med) on dopamine levels," for all the meds listed in chapter six and all of them, except for Doxepin and low dose naltrexone are connected to reducing dopamine uptake or are dopamine agonists. Low dose Naltrexone is generally used to balance cortisol levels and Doxeprin is used for reducing insomnia and has never been reported to be helpful by itself.
Olanzapine is a serotonin-dopamine-receptor antagonist
Pimozide is a medication that works by decreasing the activity of a natural substance (dopamine) in the brain
Doxepin – Doxepin was developed by Pfizer and FDA approved in 1969 as an antidepressant.11 However, in 2010 it was approved for the treatment of insomnia. It does not affect dopamine levels and is always used with one of the other medications for skin parasites. It's value is reducing anxiety and helping with sleep.
Abilify: Abilify is a “dopamine stabilizer,” meaning it can act as a dopamine receptor antagonist when the dopamine system is overactive, and a partial agonist when dopamine levels are low. It is able to do this because it has a very high affinity for dopamine receptors, so it binds to the receptor in place of dopamine.
Zolof: it has been suggested that clinically it may weakly inhibit the reuptake of dopamine, particularly at high dosages.
Seroquel: quetiapine is a dopamine, serotonin, and adrenergic antagonist, and a potent antihistamine with some anticholinergic properties.
Risperidone is an antagonist for dopamine
Wellbutrin: Bupropion is an atypical antidepressant. It acts as a norepinephrine–dopamine reuptake inhibitor
Dopamine Reuptake Inhibitors (NDRIs)
NDRIs block the action of both the norepinephrine transporter (NET) and the dopamine transporter (DAT). NDRIs are used for clinical depression, ADHD4, and narcolepsy.
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. A dopamine antagonist, also known as an anti-dopaminergic and a dopamine receptor antagonist (DRA), is a type of drug which blocks dopamine receptors by receptor antagonism. Most antipsychotics are dopamine antagonists, and as such they have found use in treating schizophrenia, bipolar disorder, and stimulant psychosis.
Lisa, from the great state of Hawaii has taken an interest in this subject. She researched it and wrote me the following with her understanding about what's happening with dopamine. Pay attention to the explanation about how parasites produce an enzyme that raises dopamine levels.
I have been trying to understand this dopamine connection and here is what I think might be going on.
1. reuptake inhibitors actually cause an increase in the extracellular
Dopamine, leading to increased CNS function ( alertness and cognitive function is improved) This is because the dopamine can not reenter the nerves as easily & quickly as normally ( a millisecond normally)
In Parasitic conditions that have been studied - specifically Toxoplasmosis which approx 80 % of Americans have this infection and don't realize it. The parasite has an enzyme that makes dopamine to excess. The high dopamine INSIDE the cell is seen in these infections in Mice ( they don't study brain tissue of humans, as you would need to biopsy the brain - not going to happen).
(Researchers believe other parasites may also have this enzyme) So contrary to what you might think the high dopamine inside the cell causes all sorts of behavior (schizophrenia, OCPD, & other) problems. The key is that: it is inside the cell where the problem happens and that is somewhere that they can not measure. You can only measure Dopamine outside the cell in the blood, fluids, etc. for living people.
This seems contrary because high dopamine is the thing that makes something addictive, so high dopamine equals good vibes. Everything that increases dopamine is what makes you feel good.
The important thing is that inside the cell high levels of dopamine cause the cell to die (too much of a good thing) or screw up other hormones. It does this by lowering prolactin , another hormone that when low causes infertility, muscle pain, PCOS (polycystic ovaries) . also lowering GH - growth hormone, and thyrotropin, thyroid hormones, and increase androgens in women ( facial hair growth), and many other symptoms.
So this is a problem with the hormones of many systems being dysregulated via the parasite. Many of the symptoms are widespread (as is toxoplasmosis) in our culture and the toxoplasmosis parasite ( carried by cats (FECES) and other intermediate hosts) once you have the cysts , they can be controlled but never eliminated, it is impossible to kill the resting toxoplasmosis parasite in the cysts, only when the reactivate and begin to multiply can they be killed.
The diet, and other programs you use will help to normalize the hormones, and bring the immune system back to better functioning so it can suppress all the parasites a bit better, but eventually the cysts will reactivate when you are stressed or go off diet etc,
I think this is why you are never "cured" but must always keep working on fighting the parasites.
I think this is also a problem for parkinsons which is when the dopamine producing cells have died out (probably from too much dopamine by a parasite), they just give them more dopamine - wrong move - now they are showing that it is too high of dopamine that cause the parkinsons and by lowering it inside the cell with those reuptake inhibitors they can help them.
Well there is a heap of natural herbal reuptake inhibitors and other types of dopamine regulators we can use yeah!!
Skullcap, StJohns wort, Melissa, Linden, green tea, flowering Quince, turkey corn, periwinkle, ashwagandha passionflower,
I thank Lisa for taking the time to research this subject and make this valuable contribution. Barbara, our herbalist is looking into a formulation using herbs.
While I research hasn't yet been done to connect the dots to dopamine levels, it's reasonable to me that high dopamine levels in the brain have a lot to do with the parasitic activation as explained by Lisa and the attraction factor experienced by many. It simply points out the need for more research. And we might find the answer using the back door. Our herbalist is working on a formula of herbs that include the above listed herbs to reduce dopamine. If it works, we will have found and confirmed the dopamine connection without having to do brain research on mice.
So, when you hear someone say that these meds are only anti-psychotic meds, call them a dope because it may all be about dopamine (pun intended) and then take a deep breadth (stress management technique) and smile at them and explain that it reasonable that perhaps parasites love dopamine and these meds lower dopamine levels in the brain and therefore they are anti parasitic medications. It has been demonstrated time and time again that those who utilize these medications find it easier to advance on the King Diet™ and get their lives back. Personally, I found pimozide as important as Nature's Gift Debriding Soap in getting my life back.